Studies on Sulfone Resistance in Leprosy
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چکیده
Almost to be expected, as the concomitant of a new chemotherapeutic agent, is the development of drug resistance by formerly sensitive organisms. Sometimes this is such a frequen t occurrence that the drug ceases to be useful ; with other drugs the appearance of resistant strains is a rarity. Throughout the twenty year experience with sulfones in leprosy, the incidence of resistance has appeared to be low. There are, however, a number of patients, both in and outside leprosaria, who are supposed to have been on adequate antileprosy treatment but fail to show the improvement expected. Wolcott and Ross (23) claimed that such patients had developed resistance to sulfones, but many leprologists could not accept this because of lack of supportive laboratory evidence. In the last few years considerable advances have been made in the study of leprosy. Work (.12, 13) on the morphologic appearance of the bacilli in stained smears taken from patients has now been brought to the point where it has been claimed (2, 22) that a change in the morphology of Mycobacteriu.m lep1'O.e can be used to assess the
منابع مشابه
Antimalarial studies on 4,4-diaminodiphenyl sulfone (DDS) and repository sulfones in experimental animals.
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